Tissue Lysates
Cayman Chemical SynthetIc HIspIdol 1mg
An aurone with diverse biological activities; is an inhibitor of tyrosinase, MAO-A, and MAO-B (IC50s = 38.4, 0.26, and 2.45 µM); increases catalase and SOD activity in cell-free assays, as well as decreases intracellular ROS in, and increases the lifespan of, C. elegans at 50 µM; decreases immobility time in forced swim and tail suspension tests in mice at 2, 5, and 15 mg/kg
Cayman Chemical C24 1 1-DeoxyceramIdem18 1 1mg
A very long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(4E)) backbone
Cayman Chemical AM694 N 5hydroxypentyl met 1mg
An expected urinary metabolite of AM694, based on the known metabolism of similar compounds; intended for forensic and research applications
Cayman Chemical SenkyunolIde I 1mg
A phthalide with diverse biological activities; inhibits TNF-α-induced NF-κB reporter gene expression in HEK293 cells and reduces LPS-induced IL-8 and IL-6 production in THP-1 cells at 100 µM; reduces acetic acid-induced writhing and increases the latency to paw withdrawal in the hot plate test in mice at 32 mg/kg; increases survival, decreases plasma levels of TNF-α, IL-1β, and IL-6, and protects against cognitive dysfunction in a mouse model of CLP-induced sepsis at 36 mg/kg
Cayman Chemical nuregulIn1 Type I2b Extra 1mg
Source: Recombinant human C-terminal His-tagged neuregulin-1 type I-β2b extracellular domain expressed in HEK293 cells • Amino acids: 20-238 • MW: 25.3 kDa
Cayman Chemical SynthetIc KhasInIn 1mg
A steroidal glycoside with diverse biological activities; reduces the proliferation of LNCaP and T47D cancer cells (IC50s = 32.1 and 27.5 µM, respectively); inhibits TNF-α-induced nuclear translocation of NF-κB in HaCaT keratinocytes at 50 nM; decreases AST serum levels in a mouse model of carbon tetrachloride-induced liver injury at 0.1 mg/kg; topical administration reduces EAr epidermal thickness and scaling, as well as leukocyte and macrophage infiltration, in an imiquimod-induced mouse model of psoriasis at 5 mg/kg
Cayman Chemical SynthetIc GW 9662 1mg
The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
Cayman Chemical 9 Z 11 E 13 Z-OctadecatrIe 1mg
An ω-5 long-chain polyunsaturated fatty acid; has been found as a major component in pomegranate seed oil; binds to the AF2 domain of PPARγ (IC50 = 2.5 µM); increases PPARα and PPARγ activity in 3T3-L1 cells in a reporter assay
